Centre for Advanced Studies, IIT Bombay,


in collaboration with the

Quantitative Life Sciences Section of ICTP, Italy,


is organizing a monthly colloquium series to be held on the 2nd Wednesday of every month.





The inaugural colloquium will be delivered by

Prof. Édgar Roldán, ICTP.

Title: Stochastic thermodynamics of active fluctuations in the ear of the bullfrog

Date: 9th March 2022 (Wednesday)

Time: 3:30PM IST / 11AM CET


Register for zoom link: https://bit.ly/QLS09Mar

Abstract: Stochastic thermodynamics is an emerging field that studies the thermodynamics of systems driven out of equilibrium in the presence of fluctuations. Unprecedented joint theoretical and experimental advances have revealed novel universal thermodynamic laws at the mesoscale, which includes fundamental constraints for biological processes. This colloquium will showcase recent progress on the application of stochastic thermodynamics to analyze fluctuations of hair-cell bundles responsible of sound transduction in the bullfrog's sacculus. Through a holistic theory-experiment approach, it has been shown that spontaneous hair-cell bundle fluctuations are nonequilibrium, i.e. active. Moreover, using time-irreversibility measures and thermodynamic uncertainty relations we have estimated the rate of entropy production of hair-bundle fluctuations in different experimental, physiological conditions [1]. Furthermore, we have introduced and solved analytically a non-Markovian model that we have employed successfully in parametric inference and to predict the minimal energetic cost required to sustain spontaneous otoacoustic emissions in the ear of the bullfrog [2].

[1] É Roldán et al., New Journal of Physics 23, 083013 (2021)
[2] G Tucci et al.,   arXiv:2201.12171 (2022)

We cordially invite you all to attend the colloquium. Please forward to other colleagues and students who may be interested.

Best regards,

Mithun, Raghu, and Amitabha